Cognitive planning deficit in patients with cerebellar atrophy.
Grafman J; Litvan I; Massaquoi S; Stewart M; Sirigu A; Hallett M.
Neurology, 1992 Aug, 42(8):1493-6.
We compared the performance of 12 patients with cerebellar atrophy
(CA) and 12 normal controls matched for age and education on the Tower of
Hanoi, a nine-problem task that requires cognitive planning. CA patients
performed significantly worse than controls on this task despite no
difference in planning and between-move pause times. A reanalysis of the
data using just the subgroup of patients with pure cerebellar cortical
atrophy (CCA) (N = 9) replicated the above results and also showed that CCA
patients had significantly increased planning times compared with controls.
Neither age, sex, education level, severity of dementia, word fluency,
response time, memory, nor visuomotor procedural learning predicted CA or
CCA performance. This deficit in cognitive planning suggests a functional
link between the cerebellum, basal ganglia, and the frontal lobe concerning
specific cognitive processes. However, the exact role of the cerebellum in
cognitive planning remains undetermined.